Signaling in the Tumor Microenvironment

In the tumor microenvironment (TME), hyaluronan (HA) can promote malignancy via signaling through cell surface receptors and activation of downstream signaling pathways that can play key roles in tumor cell survival and proliferation.1,2

HA signaling in the TME may promote2,3:

  • Cell survival
  • Cell migration
  • Cell motility
  • Cell adhesion
  • Cell proliferation
  • Tumor progression
  • Tumor metastasis