Download a comprehensive guide detailing HA accumulation in the TME.

Reduced Access

The accumulation of the glycosaminoglycan hyaluronan in the tumor microenvironment (TME) occurs in numerous solid tumors, where it can compromise both the delivery of anticancer therapeutics and access of immune cells to the tumor.1-7

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Tumor Growth and Progression

HA can stimulate tumor cell proliferation, invasion, and metastasis via signaling through cell surface receptors and interactions with stromal cells and proteins in the TME.4,5,8,9

Learn about HA’s signaling role in tumor progression →

Poor Outcomes

Elevated tumor HA levels serve as an indicator for poor survival in a number of cancers, including gastric, breast, non-small cell lung, and pancreatic cancers.1,4,10-13

See the clinical impact of HA accumulation →